Literature Review – Comparison of orthogonally estimation methods for the two-dimensional separations of peptides

Gilar, M.; Fridrich, J.; Schure, M. R.; Jaworski, A. Analytical Chemistry 2012, 84, 8722–8732.

In this recent paper the metrics used to calculate orthogonality in LC x LC were evaluated using retention data for 194 different peptides. Correlation coefficients, mutual information, box-counting dimensionality, and surface fractional coverage were all applied to determine the orthogonality of […]