New Book Chapter on 2D-LC by D. Stoll is Available Now

Dwight Stoll has written a book chapter, “Introduction to Two-Dimensional Liquid Chromatography – Theory and Practice”, in the Handbook of Advanced Chromatography /Mass Spectrometry Techniques, edited by Michal Holcapek and Wm. Craig Byrdwell, and published by Elsevier (ISBN 978-0-12-811732-3). The chapter provides an introductory view of the state-of-the-art of two-dimensional liquid chromatography, and goes on [more…]

Literature Review: Hand-Held Portable Desorption Atmospheric Pressure Chemical Ionization Ion Source for in Situ Analysis of Nitroaromatic Explosives

This study presents a novel handheld device used for “in situ” monitoring of nitroaromatic explosives (e.g. TNT) using desorption atmospheric pressure chemical ionization (DAPCI) coupled to a tandem mass spectrometer. The need for portable and relatively fast methods of detection for explosive compounds is important for security checkpoints where there is not time for samples [more…]

Literature Review: Homochiral Porous Organic Cage with High Selectivity for the Separation of Racemates in Gas Chromatography

The chirality of a molecule can vastly alter the reactions and chemical behaviors of that molecule, especially in stereospecific environments. There have been a variety of examples demonstrating that a change in chirality can make seemingly identical molecules either medically helpful or equally very detrimental to human health. With this distinction, it becomes necessary to [more…]

Literature Review: Sensitive Redox Speciation of Iron, Neptunium, and Plutonium by Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma Sector Field Mass Spectrometry

Nuclear reactions are a powerful method by which to produce energy. It is common knowledge, however, that the use of nuclear reactions to create energy also results in potentially hazardous nuclear waste. Thus, consideration must be given not only to the safety of nuclear waste repositories, but also to the possibility of detrimental compounds escaping [more…]

Literature Review: Electrospun Carbon Nanofiber Modified Electrodes for Stripping Voltammetry

Anodic stripping voltammetry (ASV) is a powerful technique capable of analysis of trace metallic components without the need for separation methods. It offers the potential for selectivity and sensitivity at relatively low cost and could be portable and therefore potentially offer analysis at the sight of sample collection. However, restrictions on the use of mercury [more…]

Literature Review: Exploring Fluorous Affinity by Liquid Chromatography

The unique interactions of highly fluorinated compounds have been observed and found to be useful in a surprising array of methods. Not only have these fluorinated compounds—Teflon perhaps being the most well-known—been taken advantage of for their characteristic inertness, but such compounds have been found to be instrumental in many highly selective separation techniques. Such [more…]

Literature Review: Construction of an Ultrahigh Pressure Liquid Chromatography- Tandem Mass Spectral Library of Plant Natural Products and Comparative Spectral Analyses

This study introduced a library of mass spectra for 289 plant natural products. These include flavonoids, isoflavonoids, and phenylpropanoids. Mass spectral data was obtained using a triple quadrupole mass spectrometer coupled to an ultrahigh pressure liquid chromatograph. The specificity of the triple quadrupole detector allows the detection of a single mass fragment after fragmentation in [more…]

Review article by Dr. Stoll appears in the journal Bioanalysis

A review article by Dr. Stoll entitled “Recent Advances in 2D-LC for Bioanalysis” was published in the December issue of the journal Bioanalysis. (doi: 10.4155/bio.15.223).

Literature Review: Controlled sp2 Functionalization of Boron Doped Diamond as a Route for the Fabrication of Robust and Nernstian pH Electrodes

The glass pH electrode has commonly been used for pH measurements, but limitations of this instrument include alkali errors, fragility, and continuous calibration. Because of these issues, efforts have been made to create robust pH electrodes for use under a range of conditions. This study presents a boron doped diamond (BDD) with sp2 carbon-quinone regions [more…]

Literature Review: Dispersive Raman Spectroscopy and Multivariate Data Analysis To Detect Offal Adulteration of Thawed Beefburgers

Meat, as defined by the European Food Standards Agency, is the skeletal muscle including natural fats and connective tissues of various species. Only certain amounts of fat and connective tissues can be counted towards the meat content of a product, and all excess must be listed separately in the nutrition label ingredient list. Such [more…]