General Interest
  1. D.R. Stoll, X. Li, X. Wang, P.W. Carr, S.E.G. Porter, S.C. Rutan, Fast, comprehensive two-dimensional liquid chromatography, J. Chromatogr., A. 1168 (2007) 3–43.
  2. D.R. Stoll, Recent progress in online, comprehensive two-dimensional high-performance liquid chromatography for non-proteomic applications, Anal. Bioanal. Chem. 397 (2010) 979–986.
  3. F. Bedani, P.J. Schoenmakers, H.G. Janssen, Theories to support method development in comprehensive two-dimensional liquid chromatography – A review, J. Sep. Sci. 35 (2012) 1697-1711.
  4. D. Li, C. Jakob, O. Schmitz, Practical considerations in comprehensive two-dimensional liquid chromatography systems (LCxLC) with reversed-phases in both dimensions, Anal. Bioanal. Chem. (2014), doi:10.1007/s00216-014-8179-8.


  1. D.R. Stoll, Guidelines for bioanalytical 2D chromatography method development and implementation, Bioanalysis 2 (2010) 105–122.
  2. N. Cassiano, J. Barreiro, R. Oliveira, Q. Cass, Direct bioanalytical sample injection with 2D LC–MS, Bioanalysis 4 (2012) 2737–2756.
  3. D.R. Stoll, Recent advances in 2D-LC for bioanalysis, Bioanalysis 7 (2015) 3125-3142.


  1. Schoenmakers, P., Aarnoutse, P., 2014. Multi-Dimensional Separations of Polymers. Analytical Chemistry 86, 6172–6179.

Pharmaceutical Analysis

  1. Zhang, K., Wang, J., Tsang, M., Wigman, L., Chetwyn, N., 2013. Two-dimensional HPLC in pharmaceutical analysis. American Pharmaceutical Review.


  1. F. Bedani, H.-G. Janssen, Using two-dimensional liquid chromatography to separate complex mixtures of peptides., LC-GC Europe 22 (2009) 248, 250–252, 254–255.
  2. Zhang, X., Fang, A., Riley, C.P., Wang, M., Regnier, F.E., Buck, C., 2010. Multi-dimensional liquid chromatography in proteomics—A review. Anal. Chim. Acta 664, 101–113.