Top 30

This is an extended version of the ‘Top Ten’, organized by subject matter. In each area, papers are listed chronologically.

Overview and Reviews

  • G. Guiochon, L.A. Beaver, M.F. Gonnord, A.M. Siouffi, M. Zakaria, Theoretical investigation of the potentialities of the use of a multidimensional column in chromatography, J. Chromatogr. A. 255 (1983) 415–437.
  • J.C. Giddings, Two-dimensional separations: concept and promise, Anal. Chem. 56 (1984) 1258A–1270A.
  • M.M. Bushey, J.W. Jorgenson, Automated instrumentation for comprehensive two-dimensional high-performance liquid chromatography of proteins, Anal. Chem. 62 (1990) 161–167.
  • G. Guiochon, N. Marchetti, K. Mriziq, R. Shalliker, Implementations of two-dimensional liquid chromatography, J. Chromatogr. A. 1189 (2008) 109–168.
  • I. François, K. Sandra, P. Sandra, Comprehensive liquid chromatography: Fundamental aspects and practical considerations—A review, Anal. Chim. Acta. 641 (2009) 14–31.
  • H. Malerod, E. Lundanes, T. Greibrokk, Recent advances in on-line multidimensional liquid chromatography, Anal. Methods. 2 (2010) 110–122.
  • P.J. Marriott, P.J. Schoenmakers, Z. Wu, Nomenclature and conventions in comprehensive multidimensional chromatography – An update, LCGC Europe. (2012) 266, 268, 270, 272–275.

Relevant, but Non-2DLC Background

  •  H. Poppe, Some reflections on speed and efficiency of modern chromatographic methods, Journal of Chromatography A. 778 (1997) 3–21.
  • U.D. Neue, Theory of peak capacity in gradient elution, Journal of Chromatography A. 1079 (2005) 153–161.

Early Theory of 2DLC
  • R.E. Murphy, M.R. Schure, J.P. Foley, Effect of Sampling Rate on Resolution in Comprehensive Two-Dimensional Liquid Chromatography, Anal. Chem. 70 (1998) 1585–1594.
  • L. Blumberg, F. David, M. Klee, P. Sandra, Comparison of one-dimensional and comprehensive two-dimensional separations by gas chromatography, J. Chromatogr. A. 1188 (2008) 2–16.
  • L.M. Blumberg, Accumulating resampling (modulation) in comprehensive two-dimensional capillary GC (GC×GC), J. Sep. Sci. 31 (2008) 3358–3365.

Theory of  Optimization 2DLC Performance

  •  K. Horváth, J.N. Fairchild, G. Guiochon, Optimization strategies for off-line two-dimensional liquid chromatography, Journal of Chromatography A. 1216 (2009) 2511–2518.
  • K. Horváth, J.N. Fairchild, G. Guiochon, Generation and Limitations of Peak Capacity in Online Two-Dimensional Liquid Chromatography, Anal. Chem. 81 (2009) 3879–3888.
  • J.N. Fairchild, K. Horváth, G. Guiochon, Theoretical advantages and drawbacks of on-line, multidimensional liquid chromatography using multiple columns operated in parallel, Journal of Chromatography A. 1216 (2009) 6210–6217.
  • G. Vivó-Truyols, S. van der Wal, P.J. Schoenmakers, Comprehensive Study on the Optimization of Online Two-Dimensional Liquid Chromatographic Systems Considering Losses in Theoretical Peak Capacity in First- and Second-Dimensions: A Pareto-Optimality Approach, Anal. Chem. 82 (2010) 8525–8536.
  • K. Horie, H. Kimura, T. Ikegami, A. Iwatsuka, N. Saad, O. Fiehn, et al., Calculating Optimal Modulation Periods to Maximize the Peak Capacity in Two-Dimensional HPLC, Analytical Chemistry. 79 (2007) 3764–3770.

Orthogonality and Separation Space Coverage in 2D Separations

  • J.C. Giddings, Sample dimensionality: A predictor of order-disorder in component peak distribution in multidimensional separation, Journal of Chromatography A. 703 (1995) 3–15.
  • M. Gilar, P. Olivova, A.E. Daly, J.C. Gebler, Orthogonality of Separation in Two-Dimensional Liquid Chromatography, Anal. Chem. 77 (2005) 6426–6434.
  • M.R. Schure, The dimensionality of chromatographic separations, Journal of Chromatography A. 1218 (2011) 293–302.
  • M. Gilar, J. Fridrich, M.R. Schure, A. Jaworski, Comparison of Orthogonality Estimation Methods for the Two-Dimensional Separations of Peptides, Analytical Chemistry. 84 (2012) 8722–8732.

Second Dimension Separation Modes and Columns

  • P. Jandera, Column selection for two-dimensional LC×LC., LCGC North Am. 26 (2008) 72–80,82.
  • F. Bedani, W.T. Kok, H.-G. Janssen, Optimal gradient operation in comprehensive liquid chromatography×liquid chromatography systems with limited orthogonality, Analytica Chimica Acta. 654 (2009) 77–84.
  • P. Jandera, T. Hájek, P. Česla, Effects of the gradient profile, sample volume and solvent on the separation in very fast gradients, with special attention to the second-dimension gradient in comprehensive two-dimensional liquid chromatography, Journal of Chromatography A. 1218 (2011) 1995–2006.

Peak Detection in 2DLC

  • S. Peters, G. Vivó-Truyols, P.J. Marriott, P.J. Schoenmakers, Development of an algorithm for peak detection in comprehensive two-dimensional chromatography, J. Chromatogr., A. 1156 (2007) 14–24.
  • I. Latha, S. Reichenbach, Q. Tao. “Comparative analysis of peak-detection techniques for comprehensive two-dimensional chromatography.” J. Chromatogr., A, 1218 (2011) 6792-6798.

Quantitation in 2DLC

  • S. Reichenbach, X. Tian, Q. Tao, D. Stoll, and P. Carr. “Comprehensive Feature Analysis for Sample Classification with Comprehensive Two-Dimensional Liquid Chromatography (LCxLC).” Journal of Separation Science, 33 (2010) 1365-1374.